Best Hypoallergenic Pillow Shams

By Katie Dyal

It’s not a sham – pillow shams really can be hypoallergenic. Contrary to popular belief, these pillow coverings aren’t just decorative. Yes, it’s true that pillow shams have a reputation for being showier than their traditional pillowcase counterparts. However, they can often tackle dust mites, bugs, and other allergens just as well. These are proof that fashionable functionality is possible. 

Using hypoallergenic pillows is a great way to keep your bed clean while adding aesthetic interest. Add accompanying inserts, and voila, you’ll have protective pillows that offer excellent allergy control. To further elevate your bed, add a couple of other decorative pillows for a stunning look that’s almost too pretty to sleep on. Keep reading to find out our top picks for the best hypoallergenic pillow shams.

Our Top Picks for the Best Hypoallergenic Pillow Shams

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Best Budget


The Brushed Microfiber Pillow Shams from NTBAY will keep allergens and other pests at bay. 

This 100-percent microfiber option is great for several reasons. Let’s start with comfort – this material is tough on allergens, but soft on your skin. Microfiber has a worn-in feel that will make you want to crawl into bed. This option is hypoallergenic as well, meaning that nothing else will crawl in your bed with you. By making the switch to hypoallergenic, you’ll increase the cleanliness of your bed environment instantly. With this purchase, you’ll get two carefully constructed pillow shams of the utmost quality. They are a standard size, measuring in at 20 inches by 26 inches, and come in a plethora of vibrant colors. When it’s time to get these sophisticated shams clean, simply throw them in the wash on cold.


Best Luxury


CaliTime’s Standard Pillow Shams will make your bed look unique and sophisticated. We chose these shams as our favorite luxury pick due to the elegant texture of their fabric. 

This option is fully made of a poly-chenille that has a velvety look and even smoother feel. This fabric is thickly woven, making it an incredibly durable and sturdy product. You won’t have to reserve these shams for just decoration  – they can handle the wear and tear. This option comes in a wide selection of gorgeous, rich colors. They’ll provide a stunning look to your bedroom, while also protecting you from any invisible irritants. In short, these are a win-win. With the purchase of this set, you’ll receive two pillow shams in a 20-inch by 26-inch size. Do your part to keep your room clean and treat yourself in the process. 

Nestl Bedding

Best Variety

Nestl Bedding

You’ll be nestling up in no time with the Soft Pillow Shams from Nestl Bedding. High-quality microfiber is carefully constructed to create these shams that are well-made and sumptuously soft. 

The fabric is double-brushed on both sides, which gives it a broken-in feel that you’ll want to snuggle up to. These shams are hypoallergenic and will keep your bed clear of unwanted visitors. You’ll sleep comfortably and worry-free knowing that you’re staying allergy-free. This option comes with an outstanding choice of 43 colors. Use these shams as an opportunity to pull the look of your room together. You can match them with your wall art, furniture or a pretty, patterned duvet cover. A decorative flange measuring one and a half inches creates a cohesive and sophisticated look, no matter which color option you choose.

THREAD SPREAD’s European Square Pillow Shams

Also Great


THREAD SPREAD’s European Square Pillow Shams will make your sleep space look incredibly posh. 

Made of 100-percent Egyptian cotton, these pillow coverings are luxuriously soft. They are made in a sateen weave that gives off just the right amount of sheen smoothness. This material also allows for excellent breathability and easy care. THREAD SPREAD’s option will give you two lovely shams in a European square style, measuring in at 26 inches by 26 inches. This traditional yet unique shape will add a new level of interest and elegance to your bed. An envelope closure is hidden in the back, making for a seamless look. What’s more, a dramatic two-inch flange border will take your pillow from sleep cushion to statement piece instantly.

What to Look For in Your Next Hypoallergenic Pillow Shams

This is a two-part process. The first part is understanding the difference between a pillow sham and a pillowcase. Pillowcases are often made of a thinner, lightweight fabric, open on the side and are considered basics in the bedding world. Pillow shams commonly exhibit decorative borders, are often made of luxurious, thicker materials and keep their closures in the back for presentation purposes. 

Now that we’ve got that part covered, it’s time to question what’s really covering your pillow insert. Does the label identify your sham as “hypoallergenic?” If so, you can move onto factors of material, design, and size. 

Material: All kinds of materials can be hypoallergenic. Pick one that will be the right fit for you in terms of comfort and maintenance. If you’re using your shams for decorative purposes, the material will also play into aesthetics. 

Design: Pillow shams are meant to be eye-catching, so have a little fun with this decision. Choose a set that sports an elegant border, interesting fabric or stand-out accent color. 

Size: Shams come in two commonly used sizes; the rectangular “Standard” and the square “European.” You’ll want to make sure the inserts you use match up in size.


Now you know that pillow shams aren’t just reserved for fancy hotels or magazine photoshoots. Use them in your own home to tie together a gorgeous bedroom look or transform a ho-hum bed set-up. The hypoallergenic kind allows you to maintain style while keeping your bed free and clear of allergens and other unwanted visitors. Through this list of recommendations, we hope we’ve led you in the right direction to your set of hypoallergenic pillow shams.

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