Best Hypoallergenic Pillowcases

By Loren Bullock

May 19th, 2022

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When it comes to your sleep space, cleanliness is so important. We don’t doubt that you wash your sheets regularly and make sure your bed stays fresh and tidy. But what if there’s more to cleaning than meets the eye? Scarily enough, the bacteria that are most damaging to your health aren’t commonly detected. 

Luckily, there are tons of hypoallergenic products on the market; pillows, bedding, mattress toppers, and mattresses are a few. Add hypoallergenic pillowcases to this list and you’ve got a team that will keep reactions away. These antimicrobial products are great at preventing mold and the invasion of dust mites, bed bugs, and other unwanted visitors. Continue on to see our top picks for the best hypoallergenic pillowcases.

Our Top Picks for the Best Hypoallergenic Pillowcases


Best Budget


Bedsure’s Satin Pillowcases For Hair And Skin ensure a safe and soft bed environment. 

This option is made out of 100-percent polyester satin, which presents multiple benefits. Satin not only looks gorgeous, but it will also make your hair and skin gorgeous as well. This material protects your beauty sleep by helping you retain moisture and preventing skin and hair cell damage. Polyester satin is also very durable; there’s a slim chance these pillowcases will ever rip or tear. They’re stain-resistant as well, so you won’t have to be too precious with this luxurious item. This set comes with two pillowcases in a standard 20-inch by 26-inch size in your choice of 14 colors. This is also your best bet if you’re watching your budget. With all of these benefits at an affordable price, what’s not to love?


Best Luxury


The 100-Percent Pure Mulberry Silk Pillowcase by Ravmix is the epitome of luxury in a pillow covering. 

Mulberry silk is the highest quality silk on the market; the silkworms stick to a strict diet of mulberry leaves, making for the consistent result of pure and sumptuous silk. Silk is an all-natural material that is completely hypoallergenic. It is also fabulous at regulating body temperature, meaning that it’s a great fabric to use all year-round. It contains amino acids that are excellent at moisturizing and protecting your hair and skin. Because of this, this all-natural material has even been proven to help with aging. They also provide a chemical-free resistance against dust mites, fungus, and mold. All in all, this option is perfect for people who have sensitive skin, sensitive allergies or both. Treat yourself to silk sheets that go with and you’ll be sleeping in luxury.


Best Variety

Bare Home

Your bed will be set when you take home the Bare Home’s Premium Microfiber Pillowcase Set. If you’re looking for cases that can match a specific color, you’ll probably find it in this option. 

This product comes with the choice of 19 rich colors, making it our best pick in terms of variety. Your purchase will come with a two-pack of 20-inch by 30-inch pillowcases that are made out of 100-percent microfiber. Microfiber is a super soft material that is especially known for its hypoallergenic benefits. With this option, you’ll stay cool in the summertime and warm in the winter. This fabric is incredibly breathable and great at regulating temperature. Microfiber ensures that this set will stay in your collection for years to come. It’s fade-resistant, stain-resistant and ranks high in durability.


Also Great

Cosy House Collection

Cosy House Collection’s Premium Bamboo Pillowcases will keep the coast clear while you crash. 

Made of a luxurious bamboo and microfiber blend, you’ll find the benefits of both in this set. First of all, these pillowcases are as-strong-as-can-be. No matter how much use they get, you won’t experience any ripping, pilling or shrinking with these. They don’t require a gentle wash either; these can be thrown in your washing machine over and over again. They are a fantastic option when it comes to ventilation. While ridding your bed of allergens, they’ll also wick away unwanted moisture. This will keep them odor-free as well while keeping you cool at night. This option offers a plethora of great colors, ranging from classic “Navy Blue” to lively “Lavender.”

What to Look For in Your Next Hypoallergenic Pillowcases

First things first; when looking for hypoallergenic pillowcases, you’ll clearly need to check the label. But what else should you look for once you’ve identified pillowcases of this kind? There are so many options out there, which is great but also hard to navigate. We’ll make it easy for you – check out material, size and quantity to get closer to your perfect option. 

Material: Believe it or not, a lot of materials can proudly sport the “hypoallergenic” badge of honor. Microfiber and cotton are probably the options you’ll see the most; however, silk, wool, and bamboo are a few others that fit the bill. All of these choices work great, so go with the one that feels most comfortable to you. 

Size: You may get so caught up in a product’s benefits that you forget to remember measurements. Pillowcases don’t always come in a standard size, so make sure your pillows and their coverings match up. 

Quantity: You’re probably used to seeing pillowcases come in sets of two, but this is not always the case when it comes to some hypoallergenic materials. Silk pillowcases, for example, are often sold solo due to their level of luxury and higher price tag.


As you can see, hypoallergenic pillowcases are effective pieces of bedding that will keep you cozy and last for years. Why go a different route when this one saves you worry and money? With this no-brainer of a buy, you can say “bye” to allergens once and for all. 

If you’re shopping hypoallergenic, read our article on how to sleep with allergies and these related articles: