Best Hypoallergenic Sheets

By Loren Bullock

Feb 20th, 2023

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What’s all the hype about hypoallergenic sheets? You may think there’s nothing special about this term, especially if non-hypoallergenic sheets have worked just fine for you in the past. But, as unsettling as it is, our sleep health is often affected by things beyond our detection. Allergens, bacteria, dust mites and bed bugs are just a few of these “things.” Why risk a pesky interaction with pests when you don’t have to? Hypoallergenic sheets can afford you that peace of mind at a price that anyone can afford. 

These hard-working sheets also maintain other benefits, such as durability and luxuriously soft comfort. Once you give these a try, you’ll see why we’re ranting. Lay your worries to rest by knowing that you’re safe and sound as you sleep. Here are our top picks for the best hypoallergenic sheets.

Our Top Picks for the Best Hypoallergenic Sheets


Best Budget

Danjor Linens

The Premium Bed Sheets Set by Danjor Linens is a wonderfully affordable and allergy-free option. 

A 100-percent brushed microfiber makes up these hypoallergenic sheets, offering a soft, velvety feel and excellent protection. With these sheets, you’ll sleep comfortably knowing that allergens are staying far away. With the purchase of this option, you’ll receive a fully elasticized fitted sheet, top sheet, and an extra generous grouping of four pillowcases. Microfiber has durability down pat. This option is built tough to resist fading, wrinkling and stretching like a champ. No matter how many times you throw these sheets in the washing machine, they’ll still retain their original state. This budget-friendly investment is a small price to pay for a sheet set that will last you years. Coming in five stunning neutrals, you’ll be able to find an option that fits perfectly in your collection.


Best Luxury


SONORO KATE’s Bed Sheet Set is a luxurious way to keep allergies away. These sheets are made of the highest quality microfiber. 

This fabric is double-brushed, making for an extra soft plushness that feels broken in from the first time you use it. The other benefits won’t go unnoticed either. No matter how much wear these sheets receive, they’ll stay fade-resistant, stain-resistant and wrinkle-resistant for as long as you own them. Two pillowcases, a fitted sheet, and a top sheet come together to complete this perfect four-piece set. Have you found a larger mattress that you love, but you’re concerned you won’t find sheets that fit it? Don’t worry – this set will have you and your mattress covered. The included fitted sheet can comfortably fit sixteen-inch deep corners.


Best Variety

Sweet Home Collection

The Supreme Collection Bed Sheets Set by Sweet Home Collection will be a sweet addition to your perfect bed frame and mattress. 

The premium comfort of these 100-percent double-brushed sheets will call to you at all times of the day and night. Beyond coziness, this fabric is incredibly durable and resistant to fading. All you’ll need to do to keep this set clean is a quick machine wash with similar colors. With an astounding choice of 45 colors and patterns, you’ll be able to match your sheets to any furniture or decor you buy for your bedroom. Go for neutral “Taupe” for a contemporary, minimalist look, or try on “Malibu” for a bright, eclectic vibe. Pretty embroidery adds subtle detail to finish off this stunning set.


Also Great 


Mellanni’s Bed Sheet Set has all the bed sheet benefits you’re looking for and more.

This option is made of 100-percent polyester fabric that has a soft, silky feel and hypoallergenic functionality. These sheets are safe, comfy, breathable and affordable to boot. This product also ranks high in terms of style – 44 color and pattern options are offered in this set, ranging from Coral to Quatrefoil Imperial Blue. Polyester has a great reputation for being strong and durable, meaning that this set can stand up to lots of wear and tear. No need to worry about wrinkling either; these sheets magically de-wrinkle on their own. With this purchase, you’ll receive a full set of sheets, including a fitted sheet with extra deep pockets.

What to Look For in Your Next Hypoallergenic Sheet Set

The term “hypoallergenic” may be a new concept for you, meaning that shopping for this type of product is a new experience for you as well. Don’t worry – finding a set that suits you is easy when you know what to look for. Compare matters of material, size, and maintenance to find your dream option. 

Material: So many different kinds of materials qualify as hypoallergenic. So, when shopping for any kind of bedding, your first priority should pertain to comfort. 

Size: Always make sure to accurately fit the size of your sheets to your bed. Depending on your mattress, you may need a set that includes a fitted sheet with deep pockets. 

Maintenance: Most hypoallergenic sheets are made of microfiber and cotton, and clean well in the wash. However, if you’re planning on going with an option like silk or wool, be aware that extra care may be required of you.

Frequently Asked Questions

What does it mean when a label says “hypoallergenic?” 

For something to be “hypoallergenic” means that it’s not likely to bring on an allergic reaction. 

What materials are hypoallergenic? 

Many materials can be hypoallergenic. Cotton, microfiber and even silk fit in this category. 

What are some other pros of hypoallergenic fabrics?

Hypoallergenic fabrics such as cotton and microfiber are often also breathable and can stand up to damage very well.


Hypoallergenic sheets work to protect you while you sleep. As you can see, abounding benefits can be found in these fabric fortresses. With one simple change to your bedroom, you can change the overall cleanliness of your bed environment. We hope that with this list you can find a protective set of your own.

If you’re interested in more hypoallergenic articles, check out our guides on how to sleep with allergies and these others: